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Is lexapro activating or sedating

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: "These findings indicate that either the co-administration of an SSRI in addition to a 5-HT3 receptor antagonist or a multimodal agent that acts as a SSRI and 5-HT3 receptor, such as vortioxetine, could enhance 5-HT neurotransmission to produce AD and antiemesis effects, similar to that of litoxetine, after long-term administration." Lecours seems to suggest that augmentation of a classical SSRI to vortioxetine may be a good idea because you have to keep this in mind (also excerpted from the study): "selective 5-HT agents alone, such as escitalopram, and multimodal agents, such as vortioxetine, alter 5-HT neurotransmission through different receptors and exert different actions, via transporter and/or receptor activity, on the serotonergic system in the hippocampus consistent with other antidepressant strategies and with a unique pharmacological profile." Supplementary, compared to other SSRIs, this study revealed: "vortioxetine has a low occupancy for the 5-HTT, escitalopram was used at a dose of 5 mg/kg in order to better mimic the effects of low occupancy alone." I'm suggesting, based upon these excerpts that I've provided from Lecours' study, that augmentation of a traditional SSRI would perhaps enhance vortioxetine's unique pharmacological effects for patients that are diagnosed with MDD? It's also possible that vortioxetine's unique mechanism of action lowers the occupancy requirement so that increased SERT blockage won't give any more benefit, just more side effects.

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Now I've been reading a few reports on a social anxiety forum, and besides the fact that seems like no one really likes this drug, and while not erasing libido it's also less helpful with mood, there is a consistency of complains about GI side effects (diarrhea, stomach ache, nausea, etc) that caught my attention.All three of these drugs cost less than \month, which is probably less even once combined than Brintellix, and Lamictal XR 250mg Lexapro 20mg Trazodone 50mg can all be taken in one handful at night. I'm also prescribed Dexedrine IR, Provigil and Xanax XR.I take Brintellix concomitant on Lamictal XR, Topamax XR, both 200mg. SSRI/SNRI wise exclusively, I have failed on Effexor XR, Pristiq and Zoloft. Vortioxetine, due to your reasoning, should be prescribed for treatment-resistant MDD, in my opinion, only after trialling an antipsychotic and failing two antidepressants from two different classes.The evidence suggests that it works at least in moderate depression but maybe less effective in severe depression.It provides an option when the patient is unable to tolerate anything else.The antidepressants are a prototypical example of the potentially complex interactions between psychiatric medications and sleep.